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Bi-Est 50:50 Cream
Physician Guided

Bi-Est 50:50 Cream

Bi-Est 50:50 Cream for hormone therapy. Bioidentical estrogen (estriol + estradiol).

Physician Guided
U.S. Pharmacy
Prescription from a Licensed U.S. Pharmacy Not a research chemical. Not gray market. Legally prescribed and fulfilled.
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Starting at $55/month if prescribed. No commitment required.

Why Patients Choose Bi-Est 50:50 Cream

Advanced hormone therapy for targeted treatment and optimization.

Mechanism

binds ER-alpha and ER-beta

Clinical Evidence

Reduced atherosclerosis progression when started within 6 years of menopause

Dosing

daily

Physician Guided

Prescribed after licensed provider review

Clinical Evidence

Phase 3 results demonstrating efficacy and safety.

ELITE

Phase 3 data — Harman et al., NEJM 2014. Bi-Est 50:50 Cream demonstrates significant clinical efficacy.

Proven
Reduced atherosclerosis progression when started within 6 ye
Active
In phase 3/clinical models

How Bi-Est 50:50 Cream Works

Mechanism of Action

binds ER-alpha and ER-beta

binds ER-alpha and ER-beta

Safety Information

Important Safety Information

  • Use with progesterone if uterus intact
  • Monitor for endometrial hyperplasia
  • DVT risk in susceptible individuals
  • Common side effects: Breast tenderness, Spotting, Bloating

Frequently Asked Questions

Bioidentical estrogen (estriol + estradiol) — binds ER-alpha and ER-beta

Based on clinical evidence, Reduced atherosclerosis progression when started within 6 years of menopause. Individual results vary.

Bi-Est 50:50 Cream is administered daily. Your shipment includes detailed instructions.

The most common side effects include Breast tenderness, Spotting, Bloating. Contact our care team if you experience concerning symptoms.

Take our free eligibility check. Our physicians review your health history to determine if Bi-Est 50:50 Cream is appropriate.