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Prescription Required Compounded by a Licensed U.S. Pharmacy Physician-Reviewed (No Office Visit) FSA/HSA Eligible Cancel Anytime

Low-Dose Naltrexone (LDN)

A 1.5–4.5mg nightly capsule that briefly blocks your opioid receptors so your body answers with an endorphin rebound. Studied off-label in Crohn's, fibromyalgia, Hashimoto's, MS, and long COVID.

4.9 (verified patients)
Monthly
$39
/month
$39 $65

$1.3 per daily dose

See if a doctor will prescribe LDN for you — 3-minute intake
Prescription from a Licensed U.S. Pharmacy Not a research chemical. Not gray market. Legally prescribed and fulfilled.
Free Shipping
Physician Guided
FSA/HSA Eligible
Cancel Anytime

How It Works

1

Answer the intake (about 3 minutes).

You'll list your condition, your meds, and what you've already tried.

2

A U.S.-licensed physician reviews your file, usually same day.

If LDN isn't right for you, you don't pay.

3

Your script goes to our 503A compounding pharmacy.

They make your exact dose (most patients start at 1.5mg and titrate to 4.5mg). It ships within 5-7 business days, in a labeled prescription bottle.

4

You take one capsule at bedtime.

Our care team checks in at week 2, week 6, and before refills.

Why Patients Choose

One capsule at night.

No injections, no infusions, no clinic visits.

Compounded at the dose your doctor picks

1.5, 3, or 4.5mg — not the 50mg tablet snapped in pieces in your kitchen.

Not immunosuppressive.

Unlike biologics, LDN doesn't lower your white count or raise infection risk.

Generic naltrexone has been on the U.S.

market since 1984. The "low-dose" use is off-label, not experimental.

$32–$45/month covers the visit, the script, and the meds.

A cash-pay rheumatology visit alone runs $300–$500.

Clinical Evidence

Clinical Trial

Multiple sclerosis — Cree et al., Annals of Neurology 2010. 8-week crossover, 60 patients. Significant improvement in mental-health quality-of-life scores; no change in physical scores. Off-label use

67%
Crohn's disease — Smith et al., Am J Gastroenterol 2007. Ope
29%
Fibromyalgia — Younger et al., Arthritis & Rheumatism 2013.

How

Standard naltrexone (50mg) blocks opioid receptors all day to treat addiction.

LDN (1.5–4.5mg) blocks them for about 4–6 hours while you sleep.

Your body reads that brief block as a shortage and answers by making more endorphins and upregulating opioid receptors. Those endorphins also act on TLR4 receptors on microglia and immune cells — the current best guess for why people with autoimmune and inflammatory conditions feel better on it.

Short version

a tiny nighttime nudge that your immune system corrects toward.

Safety Information

Important information about Low-Dose Naltrexone safety and side effects.

Important Safety Information

Warnings

Common Side Effects

Frequently Asked Questions

What Patients Are Saying

Real reviews from verified ArgoMD patients.

AH
Amanda H.
Verified Patient

Low-dose naltrexone has been life-changing for my autoimmune symptoms. ArgoMD found the right dose and my flares have decreased significantly.

March 2026
SK
Stephanie K.
Verified Patient

My functional medicine doctor recommended Low-Dose Naltrexone and ArgoMD made the compounding and delivery seamless. I'm feeling better than I have in years.

February 2026
JB
Julie B.
Verified Patient

After researching Low-Dose Naltrexone extensively, I found ArgoMD. Their physicians understood the protocol and I've seen meaningful improvement.

January 2026

30-Day Money-Back Guarantee

If you're not completely satisfied with your first month, contact us within 30 days for a full refund. No questions asked.

Safety & Compliance

Your health and safety are our top priorities.

FDA-Registered Pharmacy
Board-Certified Physicians
HIPAA Compliant
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If you've been reading about LDN for months and your doctor still won't write the script — take the 3-minute intake. A real physician will tell you yes or no. You don't pay unless they say yes.

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