A daily pill (SERM) that acts like estrogen on vaginal tissue — and only there. In the Portman 2013 Phase 3 trial (826 postmenopausal women, 12 weeks), ospemifene 60mg reduced pain during sex more than placebo.
$1.3 per daily dose
Painful sex after menopause? See if Ospemifene is right for you — 3-minute intake.Medical history, current meds, symptoms.
board-certified physician reviews your file. If ospemifene is appropriate, they write the prescription.
Take one 60mg tablet daily with food. Most women feel a difference in 4 to 12 weeks.
Portman et al. 2013 (n=826, 12 weeks): ospemifene 60mg beat placebo on dyspareunia severity.
Same trial: improvement in the "most bothersome symptom" of dryness vs placebo at 12 weeks.
One tablet a day with food.
selective on vaginal tissue, not a systemic estrogen.
Portman DJ et al., Menopause 2013 (SMART trials). Phase 3, 826 postmenopausal women with moderate-to-severe dyspareunia from vulvar and vaginal atrophy. At 12 weeks, ospemifene 60mg/day produced stati
it acts like estrogen in some tissues and blocks it in others. On vaginal tissue, it switches estrogen receptors ON, so the tissue gets thicker, more elastic, and better lubricated. On breast tissue, it does not act like estrogen. That's why it's an option for women who don't want a vaginal estrogen cream.
Important information about Ospemifene safety and side effects.
No. It's a SERM. It mimics estrogen on vaginal tissue only.
Most women notice changes between week 4 and week 12. The Phase 3 endpoint was measured at 12 weeks.
You can. Ospemifene is the option for women who don't want to use a vaginal applicator daily or weekly.
Ospemifene has an FDA boxed warning for endometrial cancer risk and cardiovascular events (similar to other estrogen-class drugs). Your physician will screen for contraindications, including a history of estrogen-dependent cancer, blood clots, or unexplained vaginal bleeding.
Not routinely for ospemifene. Your physician will follow up on symptoms and any unusual bleeding.
Yes. It's a real prescription from a U.S.-licensed physician, dispensed by a U.S.-licensed pharmacy. Ospemifene is FDA-approved (brand name Osphena, approved 2013).
Real reviews from verified ArgoMD patients.
Starting Ospemifene through ArgoMD changed everything for me. My energy, mood, and sleep all improved within weeks. The physician monitoring with regular labs is reassuring.
After years of feeling off, Ospemifene brought me back to myself. The ArgoMD team took time to understand my symptoms and found the right dose for me.
The convenience of having Ospemifene delivered monthly plus physician oversight makes this so much better than my old clinic experience. Highly recommend.
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