The first GLP-1/GIP/glucagon triple agonist. In Phase 2 (Jastreboff et al., NEJM 2023, n=338), adults at the 12 mg dose lost an average of 24.2% body weight at 48 weeks — the largest mean weight loss reported for any obesity medication in a Phase 2 trial.
$1.3 per daily dose
See if a doctor will prescribe Retatrutide for you — 3-minute intakeHeight, weight, medical history, current meds.
physician reviews your file, usually within 24 hours. If you're not a fit, you don't pay.
You inject once a week. A care team answers texts 7 days a week if you have questions or side effects.
GLP-1 (appetite, gastric emptying), GIP (insulin sensitivity), glucagon (energy expenditure). Semaglutide hits one. Tirzepatide hits two.
No daily pills. No clinic visits.
503A pharmacy. Not research-grade. Not gray market. Not "for laboratory use only."
Phase 2 trial — Jastreboff AM, et al. "Triple-Hormone-Receptor Agonist Retatrutide for Obesity." NEJM, June 2023. 338 adults, BMI ≥30 (or ≥27 with a weight-related condition), no type 2 diabetes. 48 w
Semaglutide (Ozempic, Wegovy) is a GLP-1 agonist. Tirzepatide (Mounjaro, Zepbound) hits GLP-1 and GIP. Retatrutide hits all three:
kills appetite, slows your stomach, helps insulin work.
makes your body use insulin better and stores less fat.
increases energy expenditure, which may help your body use more calories between meals.
Important information about Retatrutide safety and side effects.
Semaglutide hits one receptor. Tirzepatide hits two. Retatrutide hits three — GLP-1, GIP, and glucagon. These are different trials, so this is not a head-to-head comparison. In Phase 2, the 12 mg dose produced 24.2% average weight loss at 48 weeks, compared to roughly 15% for semaglutide and 22.5% for tirzepatide in their pivotal trials. It's the highest mean weight loss reported in obesity drug trials so far. How fast will I lose weight? Most patients see a change in appetite in the first week and start losing weight inside the first month. In the Phase 2 trial, weight loss continued through all 48 weeks without plateauing — the curve was still going down when the study ended. What's the injection like? Once a week, into the fat of your stomach or thigh, with a short needle that doesn't go into muscle. Most people compare it to a mosquito bite. Your kit includes pre-drawn dosing instructions, alcohol pads, syringes, and a sharps container. What side effects should I expect? Nausea, diarrhea, and constipation are the most common, especially during the first few weeks and when your dose goes up. They usually fade. Less common but serious: pancreatitis, gallbladder problems. Tell your physician right away if you get severe stomach pain, persistent vomiting, or yellow skin. Not for use in pregnancy or with a personal/family history of medullary thyroid cancer or MEN2. Why is this prescribed instead of Wegovy or Zepbound? Wegovy and Zepbound are FDA-approved and work well. Retatrutide is for patients who want the strongest available mechanism and are comfortable using a medicine that's still in Phase 3 trials but legally accessible through a 503A compounding pharmacy under a U.S. doctor's prescription. Will my insurance cover this? No. Compounded medications are paid out of pocket. You can use FSA/HSA dollars. The annual plan brings the per-dose cost to $113.75. What happens if my doctor says no? You don't pay. You get a written reason. You can submit additional medical records and request a second review if you want.
Real reviews from verified ArgoMD patients.
Down 47 lbs in 5 months on Retatrutide. The process was so easy — filled out the form online, doctor approved me same day, and my medication arrived 2 days later. The weekly injection is way easier than I expected.
After trying every diet imaginable, Retatrutide finally gave me the tool I needed. I've lost 32 lbs and my energy is through the roof. The care team checks in regularly which keeps me accountable.
The onboarding was seamless. I was nervous about the injection but it's so easy. I've lost 38 lbs in 4 months and my doctor says my blood work has improved across the board.
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