A once-weekly injection that turns down hunger by binding GLP-1 receptors in your brain. In the STEP-1 trial (NEJM, 2021), adults with obesity — no type 2 diabetes — lost an average of 14.9% of their body weight in 68 weeks. If you've tried willpower and it didn't stick, this is the mechanism that makes sticking to a deficit possible.
no office visit.
Your kit ships within 5-7 business days.
Message the care team in the portal for dose changes or side-effect questions.
STEP-1 trial (adults with BMI ≥30, or ≥27 with a weight-related condition, no type 2 diabetes)
No daily pill, no daily injection.
placebo in STEP-1
STEP-1 — Wilding et al., New England Journal of Medicine, 2021. 1,961 adults with obesity (no type 2 diabetes), 68 weeks. Semaglutide 2.4 mg weekly + lifestyle intervention: 14.9% mean body weight los
It does three things:
Binds GLP-1 receptors in the appetite centers of your brain — you feel full sooner, want food less often.
Slows how fast food leaves your stomach — you stay full longer after each meal.
Triggers glucose-dependent insulin release from your pancreas — blood sugar stays steadier between meals.
Important information about Semaglutide safety and side effects.
It binds GLP-1 receptors in your brain and slows stomach emptying. You feel full sooner, eat less, and your blood sugar stays steadier between meals. How much weight will I lose? STEP-1 trial average was 14.9% of body weight at 68 weeks. Some patients lose more, some less. Most people see the scale start moving in 4–8 weeks. How do I inject it? Once a week, under the skin of your stomach, thigh, or upper arm. Your kit includes the vial, syringes, alcohol pads, and a sharps container. The care team walks you through your first shot. What are the side effects? Nausea, diarrhea, and constipation are the most common — usually mild and short. Call the care team if symptoms last past two weeks or if you have severe stomach pain, persistent vomiting, or yellowing of the skin or eyes. Can I cancel anytime? Yes. Cancel in the patient portal. No phone trees, no retention scripts. Does insurance cover this? Compounded semaglutide is usually not covered by commercial insurance. You can pay with FSA or HSA funds.
Real reviews from verified ArgoMD patients.
Down 47 lbs in 5 months on Semaglutide. The process was so easy — filled out the form online, doctor approved me same day, and my medication arrived 2 days later. The weekly injection is way easier than I expected.
After trying every diet imaginable, Semaglutide finally gave me the tool I needed. I've lost 32 lbs and my energy is through the roof. The care team checks in regularly which keeps me accountable.
The onboarding was seamless. I was nervous about the injection but it's so easy. I've lost 38 lbs in 4 months and my doctor says my blood work has improved across the board.
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