An mTOR inhibitor applied to the skin. In a small Drexel trial of 13 patients with sun-damaged hand skin, 0.1% topical rapamycin reduced p16INK4A-positive senescent cells and increased collagen after 8 months of nightly use.
$1.3 per daily dose
Start your eligibility review — 3 minutes, no office visitYou apply a pea-sized amount to clean skin nightly.
(2019, n=13), nightly 0.1% topical rapamycin reduced p16INK4A-positive senescent keratinocytes in sun-damaged hand skin after 8 months.
not an off-label oral pill cut up at home.
Findings: significant reduction in p16INK4A staining (senescence marker), increased collagen VII, lower clinical aging score on the treated hand. Limits to know before you decide: small sample (n=13),
Applied to the skin, rapamycin quiets that signal locally — the trial showed fewer senescent cells and more collagen in treated skin.
Important information about Topical Rapamycin (Skin) safety and side effects.
Orally, yes. In the Chung trial, blood levels were undetectable after 8 months of nightly topical use on the hands. Your physician will still screen for contraindications.
Raw rapamycin from research-chemical sites isn't sterile, isn't dosed, and isn't legal for human use. This is the same molecule, prescribed by a U.S. physician and compounded at a licensed 503A pharmacy.
Tretinoin speeds up cell turnover. Rapamycin targets senescent cells and mTOR signaling. They're different mechanisms; some patients use both under physician guidance.
Most trial participants reported mild dryness or redness in the first few weeks. Your care team can adjust frequency if your skin reacts.
If you're not satisfied within 30 days of your first shipment, email us for a full refund.
Real reviews from verified ArgoMD patients.
I've been using Topical Rapamycin (Skin) for 3 months and the improvement in my skin is remarkable. My dermatologist is impressed with my progress.
After trying countless products, Topical Rapamycin (Skin) from ArgoMD actually delivered results. The physician guidance on how to introduce it gradually was key.
My skin has never looked better. Topical Rapamycin (Skin) paired with the protocol my ArgoMD doctor recommended has made a visible difference that friends notice.
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