Low-dose bioidentical estradiol you insert with an applicator. In the REJOICE Phase 3 trial (Simon et al., Menopause 2016), women using the 10 mcg tablet saw vaginal cell maturation, lower vaginal pH, and reduced painful sex by week 12 vs placebo.
$1.3 per daily dose
Start the 5-minute medical intake — see if you qualifyA U.S. licensed physician reviews your history, current meds, and symptoms.
no clinic visit, no faxed forms.
Message your care team anytime; they adjust if needed.
10 mcg estradiol acts on vaginal tissue with minimal systemic absorption (Eugster-Hausmann et al., Climacteric 2010).
no leaking gels or messy creams.
REJOICE Trial (Simon JA et al., Menopause 2016): 764 postmenopausal women with moderate-to-severe vulvar/vaginal atrophy. The 10 mcg estradiol vaginal insert significantly improved vaginal cell matura
After menopause, estrogen drops, those cells thin out, blood flow falls, and the tissue gets dry, fragile, and acidic-imbalanced. A small dose of estradiol placed directly inside the vagina binds those local receptors, thickens the tissue back up, restores normal pH, and reduces pain and dryness — without the systemic dose of an oral or patch HRT.
Important information about Vaginal Estrogen Tablet safety and side effects.
Local vaginal estradiol at 10 mcg keeps blood estradiol in the normal postmenopausal range. ACOG and NAMS both endorse low-dose vaginal estrogen for GSM, including for many women with contraindications to systemic HRT (discuss with the physician if you have a personal history of estrogen-sensitive cancer).
If you still have a uterus and are on systemic estrogen, yes. For low-dose vaginal estrogen alone, current guidance does not routinely require added progestogen — your physician will confirm based on your history.
Most women feel a meaningful difference between weeks 2 and 12 of consistent use. If you don't, message the care team — dose and frequency can be adjusted.
Your prescription is written by a U.S. board-certified physician and dispensed by a licensed U.S. pharmacy. Not a research chemical. Not gray market.
30-day money-back on your first month.
Real reviews from verified ArgoMD patients.
Starting Vaginal Estrogen Tablet through ArgoMD changed everything for me. My energy, mood, and sleep all improved within weeks. The physician monitoring with regular labs is reassuring.
After years of feeling off, Vaginal Estrogen Tablet brought me back to myself. The ArgoMD team took time to understand my symptoms and found the right dose for me.
The convenience of having Vaginal Estrogen Tablet delivered monthly plus physician oversight makes this so much better than my old clinic experience. Highly recommend.
Your health and safety are our top priorities.